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PH-Sensitive Nanomedicine for Treating Gynaecological Cancers

Journal: Journal of Woman’s Reproductive Health (Vol.2, No. 2)

Publication Date:

Authors : ; ; ; ;

Page : 35-50

Keywords : Gynaecological Cancers; pH-Sensitive nanomedicine; Liposomes; Polymeric micelles; Dendrimers; Nanogels;

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Emergence of various nanoscale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine.Nonetheless, theside-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remain to be a prime pitfall in curing cancers. Therefore, to achieve a better therapeutic efficacy, the use of a target-specific delivery, combined with a stimuli-responsive nanocarrier system, particularly pH-sensitive nanosystems offer an attractive strategy. Targeted drug delivery through pH-sensitive nanosystems offer the potential to enhance the therapeutic index of anticancer agents, either by increasing the drug concentration in tumor cells and/or by decreasing the exposure in normal host tissues. Therefore, nanoscale-based drug delivery through pH-sensitive nanosystems seem to be a boon for treating gynaecological cancers (as well as other cancers) without side-effects or with least harm to normal healthy tissues.

Last modified: 2023-02-27 14:13:31