Differential Pulse Voltammetry: Evolution of an In Vivo Methodology and New Chemical Entries, A Short Review

In 1924 Heyrovsky found that current at a mercury electrode was not directly proportional to the applied voltage, but there was presence of an extra-current determined by the oxidisable chemicals present in the solution. Such extra current, that is proportional to the concentration of the compound(s) oxidized and/or reduced, is called polarographic current when obtained at a mercury electrode, is called voltammetric current when obtained at all other types of electrodes 1, 2. Different types of voltammetric techniques are available the most common of which are chrono-amperometry linear voltammetry, cyclic voltammetry, and pulse voltammetry 3, 5