Test of the Activity of the Analgesic And Antipyretic Effects of Mangosteen Peel Methanol Extract (Garcinia Mangostana L.) Induction of Paracetamol in Male Wistar Rats

Methanol extract of mangosteen peel (Garcinia mangostana L.) contains saponins, alkaloids, flavonoids, triterpenoids, tannins, and polyphenols. Flavonoids in mangosteen skin can inhibit prostaglandins so that they have an antipyretic effect. Based on the background description above, a problem can be formulated: "How is the analgesic and antipyretic effect of mangosteen fruit peel methanol extract (Garcinia mangostana L.) induced by paracetamol in white male rats Wistar strain? This type of research is experimental, with a Post-Test Only Control Group Design research design conducted from March 2022 until the end of June 2022. This research was conducted at the Pharmacy Laboratory of the University of North Sumatra Medan. The amount of yield obtained from mangosteen peel methanol extract is 7.52%. After 5 hours after treatment, the body temperature of rats experienced significant changes; this was reflected in the p-value <0.05 in the mangosteen peel methanol extract group (6.75 ± 0.42 x 106 / μL) and the control group (8.31 ± 1.14 x 106 / μL) there was no significant difference in the number of leukocytes. The conclusion is that mangosteen peel methanol extract contains various phytochemicals: Alkaloids, Saponins, Flavonoids, Tannins, and Steroid Terpenoids. Methanol extract from mangosteen skin has a significant antipyretic effect (p-value ≤ 0.05) after 5 hours of administration at the optimal 750 mg/kg BW dose. Methanol extract from mangosteen peel has an analgesic effect on nociceptive pain at an optimal amount of 500-750 mg/kg body weight.