NLR AND PLR WITH PHOTOTHERAPY IN NEONATAL HYPERBILIRUBINEMIA- MAKING WAY FOR NEW DIAGNOSTIC MARKERS

Objective: The purpose of this study was to investigate the clinical significance of the platelet tolymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) in term neonates and its impact onmanagement of neonatal hyperbilirubinemia on phototherapy Materials and Methods: This observational study was conducted with 20term neonates diagnosed with neonatal hyperbilirubinemia, and recieved phototherapy. Exclusion criteria wereprematurity, post- maturity, small or large for gestational age according to week of pregnancy,babies born to mothers with GDM or pre-eclampsia and congenital defects. Results: NLR and PLR as predictors of effect of phototherapy, the sensitivity of NLR was 94.44 % while specificity was 86.36%. We noted that the sensitivity of PLR was 84.21%, while specificity of PLR was 80.95%. There was a positive correlation between TC and NLR, weak positive correlation with PLR and a weak negative correlation with lymphocyte levels. Conclusions: NLRs and PLRs were reduced due to phototherapy in term neonates, and these ratios canbe used to aid in management in term neonates with hyperbilirubinemia on phototherapy.