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Synthesis of Zinc (II)N-Benzylmethyl Dithiocarbamate as an Antibacterial against Salmonella typhi

Journal: International Journal of Pharmaceutical Sciences and Medicine (IJPSM) (Vol.8, No. 5)

Publication Date:

Authors : ; ; ;

Page : 46-52

Keywords : Antibacterial; Synthesis; Tifoid; Zink (II)N-Benzylmethyl Dithiocarbamate;

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Dithiocarbamate complex compounds are widely used as anticancer, antibacterial, and antifungal. The compound Zinc (II) N-Benylmethyl Dithiocarbamate was successfully synthesized to find a picture of the structure and antibacterial activity against Salmonella typhi bacteria. This compound was synthesized by in situ method, namely by the addition of N-benzyl methylamine, carbon disulfide, and zinc chloride, identification using FTIR, 1H NMR, and 13C NMR. Testing of antibacterial activity by disc method. The results of research from synthesized compounds using FTIR obtained groups (C-N) 1203.58, (C-H) 2918.30, (C-S) 640.37, (Zn-S) 352.97. The measurement results of 1H NMR obtained 0-3.3650 (δ CH3), 5.1256 (δ CH2), 7.3259-7.4105 (δ C6H5). The results of 13C NMR measurements were obtained 0-41.7650 (δ CH3), 60.4114 (δ CH2), 127.9929-134.7094 (δ C6H5), and 205.0874 (δ C-S2). Zinc (II)N-Benylmethyl Dithiocarbamate compound is effective as an antibacterial with a concentration of 100 ppm with an inhibitory power of 12.65 mm. Conclusion The compound was successfully synthesized and has antibacterial activity with a strong category.

Last modified: 2023-05-26 19:36:25