Justifying the Antidiabetic Ethnomedicinal Claim of Massularia Acuminata Through Its Antihyperglycaemic Activity |Biomedgrid

Iabetes mellitus is becoming the third ‘killer' of mankind, after cancer, cardiovascular and cerebrovascular diseases, because of its high prevalence, morbidity and mortality. The antihyperglycaemic activity of the leaf of Massularia acuminata that is used ethno medicinally in Nigeria in the management of diabetes mellitus was investigated is this study to justify its antidiabetic folkloric claim. Ethanol leaf extract of the plant at 100,200 and 400mg/kg was investigated for its antihyperglycaemic effect in glucose-induced hyperglycaemic rats using glibenclamide (5mg/kg) and 1% Tween 80 in normal saline as positive and negative controls, respectively. Anti-hyperglycaemic activity-directed purification of the ethanol leaf extract of the plant in glucose-loaded rats, led to the isolation and characterisation of acuminatoside by comparing its spectral data with those in the literature.