Targeting Cancer through PI3K/AKT/mTOR Pathway with Selected Natural Products (β-Elemene, Puerarin and Gypenosides) |Biomedgrid

The second foremost cause of mortality around the world is cancer; therefore correct therapy for its treatment is important. A number of therapies are in practice for the treatment of cancer, but the highly effective and less toxic treatments for cancer are natural products (NPs). These NPs cure the cancer through regulation of different pathways; such are PI3K/AKT/mTOR, NF-kB, autophagy, MEK-ERK, inflammation, oxidative stress and apoptosis. A group of natural product is sesquiterpene lactone (SLs) among which β-elemene (ELE) and Puerarin (Pue) are well known due to its anticancer activities. Other NPs, Gypenosides (Gyp) also possessed potent anticancer effect. Although these NPs have possess potential effect against cancer, but its anti-cancer mechanism through PI3K/AKT/mTOR pathway are need to be summarized. Therefore, we summarize it and hope this review will provide a baseline for further research on these compounds via PI3K/AKT/mTOR pathway.