Immune Privilege of Primary Fetal Progenitor Cells: Optimized Safety Profile of Consistent Cell Sources for Cutaneous and Musculoskeletal Regenerative Medicine |Biomedgrid

Numerous heterogenous biological tissues and cell types may be valorized and processed for therapeutic material generation and product development in regenerative medicine applications. Autologous, allogenic or xenogenic cell therapies may generally be considered for transplantation, whereas the immunogenicity of the implanted final products is key in determining treatment parameters. Banked primary fetal progenitor cells constitute highly interesting candidates for allogeneic cell therapy approaches, as among numerous other technical advantages, such cell types are devoid of the propensity towards recipient immune response eliciting. Selection of specific gestational ages for fetal organ donation procurement enables the eventual obtention of cultured progeny cell populations consistently retaining specific subsets of MHC antigens, allowing for evasion or modulation of recipient immune systems, as attested by transplantation of fetal progenitor cells in allogenic and xenogenic frameworks in Switzerland. The present study briefly summarizes the molecular, preclinical and clinical evidence supporting the immune-privileged status of primary fetal progenitor cells and the contribution thereof to the high therapeutic value of such cellular substrates for regenerative medicine applications.