Innovative preparation of Mica/Fe3O4 superparamagnetic nanocomposite as a contrast agent in MRI and MHT

Preparation of Fe3O4 and mica (mica/Fe3O4) nanocomposite as a magnetic heterogeneous nanocomposite is a new and novel idea with limited research. In most of these researches, the combination of salts containing Fe2+ and Fe3+ ions in the presence of mica and an alkaline solution has been used to prepare Fe3O4 and load it on mica. This method may lead to the non-uniform formation of Fe3O4 on the mica. Therefore, it is necessary to find alternative chemical methods that directly use Fe3O4 nanoparticles to bond with mica and form mica/Fe3O4 nanocomposites. The production method in this research is based on the co-precipitation method of superparamagnetic nanoparticles of Fe3O4 (SPMN- Fe3O4) and mica in the presence of SLS as a surfactant and urea as an adhesive. The FESEM image of the nanocomposite showed a uniform and proper distribution of Fe3O4 among the mica sheets. Evaluation of the VSM diagram of nanocomposite confirmed the superparamagnetic properties. XRD analysis of nanocomposite confirmed the existence of two phases, SPMN-Fe3O4 and mica. A simulation of MHT therapeutic operation is performed to explain the MHT process and show one of the applications of mica/Fe3O4 nanocomposite in cancer treatment.