QUINAZOLINE: UNIQUE AND VERSATILE PHARMACOPHORE IN THE FIELD OF CANCER

Quinazolines are the most important class of heterocyclic compounds. Quinazoline is a bicyclic compound consisting of a pyrimidine system fused at 5, 6 with benzene ring Quinazoline is considered as an important chemical synthesis of various physiological significance and pharmacological utility. Cancer is a disease characterized by uncontrollable, irreversible, independent, autonomous, uncoordinated and relatively unlimited and abnormal over growth of tissues. The drugs containing Quinazoline groups were the first effective chemotherapeutic agents which were systematically proved for the prevention and cure of bacterial infection in human beings. Literature revealed that Quinazoline derivatives may serve as an important model on as potent anti-cancer agent. When one biological active molecule is linked to another, resultant molecule generally has increased potency. Most of the derivatives showed enhanced anti-cancer activity. So, Quinazoline derivatives can serve as future therapeutic leads for the discovery of anti-cancer drugs. This review was focused on the Quinazolines and its different derivatives that posses anticancer activities. Keywords: Quinazolines, Cancer, Cytotoxic Activity, Antiproliferative Activity, Antitumor activity.