FORMULATION AND EVALUATION OF CATIONIC NIOSOMES OF 5 - FLUORO URACIL

Cancer is the second leading disease associated with combinations of chemotherapy, radiation treatment. The conventional tr eatment is limited due to its si de effects. 5 - fluorouracil encapsulated cationic vesicles form complexes with negativ ely charged cell or endoplasmic membrane and facilitate in drug release after endocytosis. multi lamellar and large uni lamellar vesicles without aggregation are obtained. The encapsulation efficiency and drug release increased with increase in stearyl ami ne. Cationic vesicles showed steryl amine dependent drug release. Key Words : 5 - fluorouracil, encapsulation, cationic vesicles, stearyl amine