SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL MANNICH BASES OF NORFLOXACIN DERIVATIVES K. Satyamurthy * , M. Sravani, M. Sowjanya, M. SrikanthReddy, M. Jaishankar, G. Kalyani

Ntroduction of Furoquinolone moiety, in the synthesis and Biological evaluation of novel mannich bases of Norfloxacin derivatives. The synthesized product was characterized by IR &H 1 NMR and evaluated for antibacterial activity by cup plate method and tub e dilution method . The activity of all synthesized compounds has shown good to mild activity aga inst tested microbes. The compound IId has shown good activity for gram positive bacteria , where as the compound IIe has shown good activity for gram negative ba cteria and compounds IIa, IIb and IIc shows moderate activity. Key words: Furoquinolone moiety, IR, H 1 NMR, Cup plat e method, Tube dilution method