PREPARATION AND EVALUATION OF CIPROFLOXACIN DRY EMULSION CONTAINING SUSTAINED RELEASE BEADS BY I ONTOPHORETIC GELLATION METHOD Patil Bhagyashree Subhash*, M. A. Bhutkar , Tina Raju, Tanushree Sarkar, Dr. S. K. Mohit

The objective of the current investigation is to reduce dosing frequency and improve patient c ompliance by designing and syst ematically evaluating sustained release micro beads of Ciprofloxacin. Method: Ciprofloxacin - loaded microbeads were successfully prepared by ionot ophoretic gel l ation and cross linking technique using sodium alginate as the hydrophilic carrier and calcium chloride as cross linking agent. Prepared beads were evaluated for particle size, swelling ratio, drying rate, drug entrapment , bio adhesion study, in vitro rele ase kinetics. Differential scanning calorimetry, Fourier transform infrared spectroscopy were performed in order to determine the stability of the formulation and the presence of drug excipient interactions, Scanning electron microscopic studies were carri ed out to find the morphology of the microbeads. Particle size distributions of drug loaded formulations were measured by an optical microscope. stability study. Particle size distribution of both placebo and drug loaded formulations were measured by an op tical microscope and particle size of optimized beads was determined by SEM. No significant drug - polymer interactions were observed in FT - IR studies. In - vitro drug release profile of Ciprofloxacin micro beads was examined in phosphate buffer pH 6.8 . Keywor ds : Ciprofloxacin , HPMC, Chitosan , Dry Emulsion