Response of Injured Lung to Qiapi 1© Treatment in Rats Exposed to Penta-Valent Arsenic |Biomedgrid

The main function of lungs is to perform the exchange of CO2 with the alveolar air from atmosphere. At the respiratory membrane, where the alveolar and capillary walls meet, gases move across the membranes, with the carbon dioxide exiting from bloodstream. It is through this mechanism that blood carbon dioxide, the waste product of cellular metabolism, is removed from the body. The particularities of normal gas exchange require ventilation, perfusion, a normal alveolar surface, and energy. The respiratory membrane is highly permeable to gases; the respiratory and blood capillary membranes are very thin; and there is a large surface area throughout the lungs. There are many toxic compounds in the environment that cause hampering pulmonary defense against bacterial and viral infection in humans and animals during acute or chronic exposition, however, their mechanisms of suppression of pulmonary host defense are not well understood. It is likely that the combination of epithelial cell injury and inhibition of macrophage function may be responsible for the suppression of pulmonary host defense. In this study we expose tri-valent arsenic to different groups of Wistar rats. There are a control group, an exposed group, and a third group that simultaneously was exposed and at the same time treated with a novel therapeutic agent (QIAPI 1©). At the end of the study of four months, the animals were sacrificed, and inner organs studied. In this report we are describing the histological lung results.