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Synthesis of 3, 4-Dihydropyrimidin-2-(1H)-ones Using a Hydrogel as a Green and Reusable Catalyst

Journal: Chemical Methodologies (Vol.8, No. 3)

Publication Date:

Authors : ; ; ;

Page : 154-163

Keywords : Hydrogel; Biginelli reaction; Multi-component reactions;

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The primary objective of this study was to devise a straightforward and environmentally sustainable approach for creating Biginelli compounds. Accordingly, a p(AMPS) hydrogel served as an effective catalyst of diverse nature, facilitating the preparation of 3,4-dihydropyrimidine-2-(1H)-ones, commonly recognized as Biginelli compounds. The chemical process unfolded using an eco-friendly method, resulting in notably abundant product yields. Moreover, the catalyst exhibited remarkable reusability, maintaining its efficacy through four cycles without a substantial decline. The innovative Biginelli reaction technique achieves environmentally conscious synthesis, robust product generation, simplified isolation procedures, catalyst sustainability, and avoids harmful by-products.

Last modified: 2024-02-28 05:40:18