Voltammetric Sensor for Acyclovir Determination Based on MoSe2/rGO Nanocomposite Modified Electrode

In this study, MoSe2/rGO nanocomposite modified screen printed graphite electrode (SPGE) was designed for acyclovir (ACV) determination. The electrochemical investigation and measurement of ACV were performed by applying some voltammetric techniques and chronoamperometry. After modification of SPGE, the enhancement of the voltammetric response and the reduction of overpotential of ACV confirmed the good electrocatalytic ability of MoSe2/rGO/SPGE sensor towards the ACV oxidation. The voltammetric method (differential pulse voltammetry (DPV)) was used to investigate the determination ability of MoSe2/rGO nanocomposite/SPGE towards ACV determination under the optimum parameters and conditions. The MoSe2/rGO/SPGE sensor indicated appreciable sensing ability towards ACV, with an optimal linear response from 0.03-190.0 µM and a limit of detection (LOD) of 0.01 µM. More importantly, the practical applicability of the designed sensor was confirmed in the ACV quantification in ACV tablet and urine samples, showing its potential application for real sample analysis.