The Renalase (rs2296545) Polymorphism is Associated with End-Stage Renal Disease

—Renalase is a recently identified enzyme that is dependent on flavin-adenine dinucleotide and acts as an amine oxidase. It is secreted by the kidney. It travels through the bloodstream, where it impacts the functioning of the heart and the overall blood pressure in the body. The study was conducted in Babylon between February and July 2023. (50) Blood samples were obtained from patients who were admitted to the Merjan Teaching Hospital in Babylon Province, Iraq, and were diagnosed with severe renal illness. The control group comprised 50 samples of healthy individuals spanning an age range from 11 to 80 years. The present investigation observed that the average fluctuation in renalase level (expressed in picograms per millilitre) was similar in both the patient and control groups. The serum of end-stage renal disease groups exhibited significantly elevated levels of renalase (P<0.05) compared to the healthy participant group (170.21 ± 4.97 pg/ml vs. 40.06 ± 7.21 pg/ml). The findings revealed that the frequencies of CC, CG, and GG genotypes of the renalase (RNLS) gene in individuals with end-stage renal failure were 19.6%, 39.3%, and 41%, respectively, whereas in the control group, the frequencies were 53%, 25.6%, and 21.4%. Conclusion: The presence of the Renalase mutation (rs2296545) C>G mutation in the Iraqi population was found to be linked to an increased susceptibility to end-stage renal failure