Research Progress on Hair Cell Injury and Related Regenerative Mechanisms |Biomedgrid

Inner ear hair cells are a central component of the auditory system. However, it is susceptible to genetic defects, noise exposure, ototoxic drugs, and aging, because mammals have limited ability to regenerate spontaneously, hair cell loss or damage may lead to permanent hearing loss. Although cochlear implantation, gene therapy and antioxidant drugs employment are effective methods to treat hearing loss, the related effects are not ideal. By searching Pubmed, CNKI, Wanfang and other large databases, this review summarizes the damage mechanisms of cochlear hair cells mainly involve the breakage of tip links, mechanical damage of the core of the ciliary fiber actin, synaptic damage, as well as Oxidative stress by ROS intervention system. At the same time, the mechanism of hair cell regeneration may be related to gene regulation and epigenetic mechanism. In the future, with the continuous focus of research hotspots, the mechanism of inner ear hair cell regeneration and the therapeutic drugs derived from it will gradually be explained clearly.