Analysis of the genetic determination of developing eventration in patients with abdominal surgical pathology

Eventration is one of the most dangerous complications in abdominal surgery, which occurs in 0.2-7% (2% on average) of patients after laparotomy. The event leads to the development of intestinal obstruction, postoperative peritonitis, and the formation of intestinal fistulas. Despite the fact that the role of impaired regeneration and repair processes in the occurrence of events is undeniable, scientific publications and research at the modern methodological level on this topic are insufficient, and existing ones mainly concern the development of postoperative ventral hernias. The purpose of the study was to conduct an analysis of genetic determination of the development of eventrations, based on the frequency of polymorphic variants of matrix metalloproteinase-2 (C-1306→T) (MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (G303→A) (TIMP-2) genes. The subjects of the study were 19 patients with eventrations and 44 patients with connective tissue pathology. The data obtained by us from the study of polymorphic variants of the MMP-2 (C-1306 →T) and TIMP-2 (G303→A) genes in the Ukrainian population generally correspond to the population frequencies in the European population and the USA. All models of inheritance were analyzed, and the best model with the lowest Aikaike information criterion was determined, which turned out to be a recessive model. As a result of the genetic and statistical analysis of polymorphism of MMP-2 (C-1306 →T) and TIMP-2 (G303→A) genes, it was established that polymorphic variants of these genes are not reliably associated with the development of eventration.