SIRNA: ITS TRANSLATIONFROM RESEARCH TO THERAPEUTIC APPLICATIONS

Small interfering RNA (siRNA) is a short, double-stranded RNA molecule that has emerged as a pivotal tool for gene silencing through the RNA interference (RNAi) pathway. It is a powerful post-transcriptional gene-silencing molecule central to RNA interference (RNAi) mechanisms1. Typically 21 25 nucleotides in length, it guides the RNA-induced silencing complex (RISC) to a target messenger RNA (mRNA), enabling sequence-specific degradation and effectively silencing gene expression2.