Evaluation of Treatment Outcome for HIV Patients after TLD Regimen (Tenofovir, Lamivudine and Dolutegravir) using Viral Load Suppression

Introduction: HIV is a virus that weakens the immune system of a person by destroying cells that fight against infection and disease. Dolutegravir-based regimens (TLD/ALD) were suggested by the WHO as the preferred first- and second-line antiretroviral therapy in 2018. Objective: To evaluate the treatment outcome of TLD regimen based on viral load suppression among HIV patients. Methods: A prospective observational study was conducted in government general hospital, Ongole for a period of six months. Efficacy of TLD regimen among 470 patients was assessed. Results: Our study involves 3,110 patients out of which 470 patients are included who are having age between 20-50 years old, undergoing TLD therapy, who are under follow up and whose medication adherence is documented. Of these patients, 321 individuals (68%) had virologic response to the TLD regimen, while virologic response was not achieved in 149 patients (32%). Conclusion: According to the results of our study, we conclude that the TLD regimen is 68% effective, andPatients in clinical stage 1, who had >95% adherence, were working, between the ages of 20 and 30, females showed better results in terms of viral suppression.