Role of Breast Conservation Surgery in Patients with Locally Advanced Breast Carcinoma after Neoadjuvant Chemoradiotherapy

Background: Locally advanced breast cancer (LABC) constitutes more than 50 to 70% of the patients presenting for treatment. Today treatment of LABC requires a combination of systemic and local/regional therapies. The most common approach for treating Locally Advanced Breast Carcinoma in developed countries consists of neoadjuvant chemotherapy with anthracyclines and taxanes followed by surgery and radiation therapy; hormonal treatment is added for receptor-positive disease, and patients with Her2neu-positive disease receive trastuzumab therapy. Objective: To evaluate, compare and study the role of Breast conservation after neoadjuvant chemoradiotherapy in terms ofMargin infiltration of excised specimen, Ipsilateral reoccurrence, Patient satisfaction and Survival rate. Material & Method: Prospective study performed from August 2019 to August 2020 in the department of General Surgery and Radiotherapy in SN Medical College, Agra on patients with locally advanced breast carcinoma operated with Breast conservation after neoadjuvant chemotherapy. Total numbers of patients included were 60. Clinical assessment of all the cases was carried out and Tissue obtained from breast biopsy as well as postoperative specimen was sent to pathology department for H and E staining to assess the histological tumor type and grade in accordance with Modified Bloom Richardson histological grading system and immunohistochemistry. Statistical analysis was done and P values < 0.05 were considered significant. Conclusion: Breast conservation surgery is safe and effective alternative to mastectomy in patients with locally advanced breast carcinoma for patients treated with neoadjuvant chemotherapy.