Biological Activity of Polyene Antibiotics and Their Use in Improving the Environment

It has been shown that in the complex use of polyene antibiotics with dimethylsulfoxide, the biological activity of antibiotics sharply increases. Comparative physicochemical characteristics of dimethylsulfoxide and polyene antibiotics are presented. Effects of complex interaction of dimethylsulfoxide and polyene antibiotics with bilayer lipid membranes are considered. By the method of bilayer lipid membranes parameters of biological activity of polyene antibiotics are determined. It is shown that amphotericin B and levorin were the most effective among all polyene antibiotics s studied. The results of the dependence of the ionic conductivity of lipid membranes on the concentration of amphotericin B and levorin and on the concentration of cholesterol in membranes are presented. On the basis of polyene antibiotics, effective membrane-active preparation against viral and fungal diseases of plants have been developed.