Synthesis of Schiff Base Metal Complexes of Sulfapyridine and Pyridine, Their Characterization and Biological Studies

Metal complexes of sulfapyridine are attracting the pharmaceuticals due to their enhanced biological activity. In recent study, on condensing sulfapridine and pyridine-2-aldehyde a Schiff base (N-pyridin-2-yl-4-[(pyridin-2-yl) methyl amino]benzene sulfonamide is synthesized. This ligand is complexed with metal ions and form stable complex. It can bind up with metal ions because it has two binding sites, one is pyridinyl nitrogen and the other is azomethine nitrogen atom. Characterization of ligand and metal complexes formed is done with IR, NMR, 1H NMR and elemental analysis. Then their biological activity was observed against Pseudomonas aeruginosa, Staphylococcus aureus bacteria and against fungi Aspergillus niger, Candida. It was observed that the complexes have more pronounced biological activity than the Schiff base.