Oral microbiota importance in the development and prognosis of oropharyngeal region oncological diseases

Relevance. Despite many years of scientific research and clinical results, cancer remains a global health problem. In recent years, there has been an increased interest in studying the role of microorganisms in the occurrence, prognosis and progression of cancer. The probability of isolating carcinogenic microorganisms in the oral microbiota is quite high. In this regard, understanding the role of microorganisms in the occurrence and course of cancer pathology in the future can contribute to the development of innovative strategies for the prevention, treatment of malignant neoplasms and minimization of complications of antitumor treatment. The purpose of this review is a literature analysis of the relationship between representatives of the human oral microbiota in the occurrence and prognosis of cancer. Collection and analysis of 1050 scientific papers using PubMed, Google Scholar and eLIBRARY search engines, published from 2003 to 2024, of which 47 papers are included in this literature review. According to the literature analysis, prevention, diagnostics and treatment of oncological diseases can and should be supplemented by dental approaches aimed at normalizing the microflora. Understanding that oral sanitation significantly reduces its bacterial contamination and, as a result, reduces the number of pathogenic and oncogenic microorganisms can improve the quality of antitumor treatment without significant material and social costs. Conclusion. The use of modern methods of diagnostics and monitoring of oral microbiota in dentistry can become the basis for the development of new strategies for the prevention and treatment of malignant neoplasms of the oral mucosa. Integration of these data into clinical practice requires interdisciplinary cooperation between oncologists, microbiologists and dentists to improve the prognosis of patient treatment.