CENTRAL NERVOUS EFFECTS OF C - TYPE NATRIURETIC PE PTIDE AND NUCLEAR FACTOR KAPPAB ; IMPLICATIONS IN CARDIOVASCULAR STRESS

Hypertension is a multifactorial and chronic disorder of elevated blood pressure. Persistent hypertension is deleterious for h umans and may cause morbid changes in the organs e.g heart, kidneys, brain and the eyes. Natriuretic peptides i.e atrial, brain and C - type are secreted by the heart and are synthesized in other part s of the body. CNP is present in many discrete regions of the central nervous system ( CN S ) . In this study , the effect of natriuretic peptides on memory and cognition, plasticity and behaviour are evaluated and reviewed . In this review the focus is on the C - type natriuretic peptide and its interaction with the nuc lear factor kappa B ( NFkappaB ) in the central nervous system and implications in conditions of cardiovascular stress.