FORMULATION AND EVALUATION OF GASTRO - RETENTIVE FLOATING TABLET OF QUETI A PINE FUMARATE

The present research work is on gastro retentive floating matrix tablet of Quetiapine fumarate by using various hydrophilic polymers The formulation was developed by using different concentrations of polymers of various grades of HPMC and guar gum. Then Gas generating agent sodium bicarbonate concentration was optimized The formulation blend was subjected to various preformualation studies, and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared by using Guar gum were unable to produce desired drug release; they were unable to retard drug release up to 12 hours. The formulations prepared with HPMC K 15 M retarded the drug release up to 12 hours in the concentration of 120 mg (F6).The formulations prepared with HPMC K100M (F8) were also retarded the drug release for more than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Higuchi mechanism of drug release. Keywords: Quetiapine fumarate , HPMC polymers , Floating tablets. Gastro retentive