Prevention of Opioid Use Disorders for Veterans with Chronic non Cancer Pain and PTSDJournal: Journal of Addiction & Prevention (Vol.1, No. 1)
Publication Date: 2013-06-30
Psychological trauma is a major predictor of opioid dependence, with the risk of intravenous drug use being increased nine-fold in individuals with a history of early trauma  and a co-morbid rate of 33% in adults with post traumatic stress disorder (PTSD) . The comorbidity of PTSD and opioid dependence complicates treatment of both conditions. Thus, most clinical trials for the treatment of opioid dependence have excluded participants with co-occurring psychiatric disorders, including PTSD. The few treatment studies in patients with PTSD and opioid dependence have reported poor outcomes for both conditions. PTSD patients report a reduction in intrusive and hyperarousal symptoms of PTSD with acute opioid use  and studies in children with burn injuries have shown that acute morphine administration protects against the development of PTSD in children who are burn victims [4-6]. Therefore, patients with PTSD have high risk of developing opioid addiction.
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