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Genetic Study of Three Closely Linked X chromosome STR Markers in an Argentinian Population

Journal: Journal of Forensic Investigation (Vol.1, No. 2)

Publication Date:

Authors : ; ; ; ; ;

Page : 01-04

Keywords : DNA typing; Short tandem repeats; X chromosome; DXS10079; DXS10074; DXS10075;

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Three closely linked X chromosome markers (DXS10079, DXS10074 and DXS10075) were evaluated in a sample of 213 unrelated individuals (106 women and 107 men) from Buenos Aires (Argentina). Hardy-Weinberg equilibrium (HWE) was tested in the female sample and no significant deviations were observed. Homogeneity of allele frequencies of men and women was compared by Fisher’s exact test and showed similar distributions. Overall linkage disequilibrium (LD) tests were performed in males for all pairs of loci and significant associations were detected only in the pair DXS10074-DXS10075. However, significant inter-allelic associations were detected among the three markers when the disequilibrium coefficient (D’) was estimated. Comparison of allele frequencies among Argentinian, Asian, European, and Latin American populations was performed and parameters of forensic interest were also estimated.

Last modified: 2015-06-23 17:41:33