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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.2, No. 6)

Publication Date:

Authors : ; ; ; ; ;

Page : 1048-1056

Keywords : iajps; Gefitinib; Rapidly disintegrating tablets; Direct compression; Solid dispersion;

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Objective: The main objective of the Oral disintegrating tablets is to enhance absorption and bioavailability of the drug by Preparation of standard calibration curve for Gefitinib and by Preparation of rapidly disintegrating tablets of Gefitinib by using direct compression of the solid dispersion prepared. Method: Solid dispersions are prepared by using different carriers like Urea. Here, required weighed quantities of drug and Urea are weighed and are made to dissolve in 10 - 20 ml of Methanol .Then using magnetic stirrer with hot plate the solvent is evaporated and clear film of drug and carrier was obtained. Then the amount of drug equivalent to 25mg and carrier equivalent to 50 mg are weighed and to it the remaining ingredients are added .The tablets are prepared by Direct compression. Result: The results obtained in the in - vitro dr ug release were tabulated for F1 to F12 formulations. The formulations F1,F2,F3 showed release upto 79.78%,81.67%,92.45% respectively. The formulations F4,F5,F6 showed release of 98.28%,92.18%,90.28% while the formulations F7,F9 showed drug release of 94. 45%,94.45% while the formulations F10,F12 showed drug release of 86.52%,83.88%. The drug release was completely achieved in a short duration of time. Finally, % drug release of formulation v/s time (in min) was estimated. Conclusion: Among all the 12 formu lations F4, F7, F9 are the better formulations showed high in - vitro dissolution rate than the other formulations, of which F4 was expected formulation for rapid release. Key Words: Gefitinib, Rapidly disintegrating tablets, Direct compression, Solid dispersion

Last modified: 2015-07-13 21:07:48