SYNTHETIC STUDIES ON NOVEL NITROQUINAZOLINONE ANALOGS WITH ANTIMICROBIAL POTENTIALJournal: Bulletin of Pharmaceutical Research (Vol.3, No. 2)
Publication Date: 2013-08-31
Authors : Rajiv Dahiya Rita Mourya;
Page : 51-57
Keywords : Quinazolinones; 4-Nitroanthranilic acid; Peptide analogs; Coupling; Antifungal activity;
A novel series of 4-[2-(3-bromophenyl)-7-nitro-4-oxo-3,4-dihydro-3-quinazolinyl]benzoyl amino acids and di/tripeptides was synthesized using diisopropylcarbodiimide (DIPC) as the coupling agent and N-methylmorpholine (NMM) as the base. Structures of all the newly synthesized peptide analogs were elucidated using IR, 1H/13C NMR, MS spectral data and evaluated for antimicrobial potential against pathogenic microbes. Most of the compounds exhibited potent antifungal activity against pathogenic Candida albicans and dermatophytes, in comparison to reference compound. Good bioactivity was also seen against gram-negative bacteria for synthesized compounds.
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