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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.2, No. 8)

Publication Date:

Authors : ; ; ; ;

Page : 1206-1215

Keywords : Quetiapine fumarate; HPMC K15M; HPMC K100 M; Guar gum; Controlled Release tablets.;

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In the present work, an attempt has been made to develop controlled release tablets of Quetiapine fumarate by selecting different grades of HPMC and Ethyl cellulose as retarding polymers. All the formulations were prepared by direct compression method using 12mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F3 formulation showed maximum % drug release i.e., 97.3 % in 8 hours hence it is considered as optimized formulation. Whereas the formulations containing HPMCK100M showed more retarding with increasing concentration of polymer. The formulations with Guar gum were unable to produce the desired rug release pattern. Key Words: Quetiapine fumarate, HPMC K15M, HPMC K100 M, Guar gum, Controlled Release tablets.

Last modified: 2015-09-12 22:25:19