FORMULATION AND EVALUATION OF AMPICILLIN LOADED NANOPARTICLES

The objective of this study was to prepare ampicillin?loaded nanoparticles for controlled delivery through the intravenous (i.v.) route to reduce the frequency of administration, increasing the bioavailability. Ampicillin nanoparticles were prepared by Desolvation method and characterized for drug content, particle size and size distribution, zeta potential, and in vitro drug-release study. In this method the Bovine Serum Albumin nanoparticles were prepared by Desolvation technique. Ampicillin Belonging to the penicillin group of beta-lactam antibiotics.It is used for the treatment of infections known to be or highly likely to be caused by bacteria. All formulations were further checked for evaluation parameters. Particle size of all formulation was found to be 200 to 500nm. Zeta potential for all formulated nanoparticles were in the range of 64.1which indicates excellent stability. The maximum percentage yield was found to be 78.66% for the formulation F4.The maximum drug content was found to be 71.90% for the formulation F1.The cumulative percentage release after 11 h was found to be 53.24 to 75.60.From results it was observed as increase polymer concentration, drug release from the nanoparticles decreases. Keywords: Bovine serum albumin, Nanoparticles, Ampicillin.