ИССЛЕДОВАНИЕ МЕТАБОЛИЗМА ПУРИНОВЫХ НУКЛЕОТИДОВ, ПРООКСИДАНТНОЙ И АНТИОКСИДАНТНОЙ СИСТЕМ У БОЛЬНЫХ РАКОМ ЖЕЛУДКА

It was studied the status of the pro- and antioxidant systems in the cancer and non-malignized tissues of patients with stomach cancer in depend on the disease stage as well as interrelations between pro/antioxidant systems and nucleotides metabolism. The cancer and adjacent tissues of 26 patients 60-79 years aged were studied. The activity of purine metabolism enzymes ? adenosine deaminase (ADA) and xanthine oxidase (XO) which has the prooxidant ability were determined as well as the activity of antioxidant defense enzyme ? glutathione peroxidase (GP) and superoxide dismutase (SOD), levels of nitrates/nitrites (NOx). The activities of enzymes were measures by spectrophotometery