Changes in left ventricular systolic function in patients with chronic heart failure with preserved ejection fraction and cardiorenal anemic syndrome

The feature of chronic heart failure (CHF) in elderly people is increasing incidence of heart failure with preserved left ventricular ejection fraction (LVEF) which is associated with age. Such patients account for almost half of the total number of patients with heart failure. Cardiorenal syndrome (CRS) is associated with an increased risk of mortality in patients with CHF. The impact of CRS on the structural and functional condition of the heart in these patients is studied insufficiently. The study involved 103 patients with CHF II-IV NYHA with preserved LVEF (>45%) and CRS (hemoglobin <120 g/l and < GFR 60 mL/min/1,73m2 (MDRD). It is established that during progression of anemia and diastolic dysfunction development of concentric hypertrophy is observed, it is accompanied by deterioration of LV systolic function, namely by the increase of end-systolic volume and decrease in the degree of LV fractional shortening size.