SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF Cu (II), Ni (II) AND Zn (II) COMPLEXES WITH CURCUMIN AND METHYL SALICYLALDEHYDE

Curcumin, the major active component of the spice turmeric, which is considered to be a very useful compound in health matters, is recognized as a safe component with great potential for cancer chemoprevention and cancer therapy. The paper presents the synthesis of complex combinations of Cu(II), Ni(II) and Zn(II) with Schiff base obtained by the condensation reaction of curcumin, hydrazine hydrate, methyl salicylaldehyde . The structural features have been arrived from their FT-IR, 1H NMR, 13C NMR, mass, UV-vis spectroscopic studies. The binding behaviours of the synthesis complexes towards calf thymus DNA have been investigated by absorption spectra, emission spectra, viscosity measurements and circular dichroic studies. The DNA binding constants reveal that all these complexes interact with DNA via intercalating binding mode with binding constants (Kb) of 4.72 x 104 M-1 , 3.89 x 104 M-1 and 3.13 x 104 M-1 and Kapp of 5.26 x 105 M-1 , 4.37 x 105 M-1 and 3.91 x 105 M-1 . Keywords: Curcumin, DNA binding, Viscosity, Intercalation, methyl salicylaldehyde