Development and evaluation of sustained release microparticles of Ketorolac Tromethamine

The aim of the present study was to prepare and characterize microparticles for delivery of Ketorolac Tromethamine using EudragitRS100, ethyl cellulose, hydroxy propyl methyl cellulose E5 as polymeric retardant material. Microparticles were prepared by oil-in-oil emulsification method. The effect of process variables on microparticle size, percentage yield, percentage entrapment efficiency and in-vitro release characteristics of microparticles were studied. FT-IR and thin layer chromatography were performed to evaluate interaction between drug and polymer. Morphology of microparticles were characterized by scanning electron microscopy and found that the microparticles were spherical with rough surface. Mechanism of release was found Higuchi and Korsmeyer-Peppas type. This study indicated that the sustained release microparticles of Ketorolac Tromethamine could be prepared successfully by using emulsion solvent evaporation technique.