Formulation and Evaluation of Poorly Aqueous Soluble Drug by Solid Dispersion Method

Development of solid dispersions of poorly water soluble drugs is one of the most widely used approaches to enhance the solubility as well as dissolution rate. In the current investigation, Ezetimibe is selected as model drug to improve the solubility and dissolution rate by solid dispersion method. Solid dispersions were prepared using solvent evaporation method by incorporating sol plus as carriers in different ratios and evaluated for solubility studies, FT-IR, X-Ray, DSC studies and in vitro dissolution studies. Based on the solubility and drug release studies, formulations different disintegrates are used and the best natural disintegrating agent i.e. Guar gum was selected to prepare the tablets and in vitro dissolution study is done, tablets containing Guar gum showed almost complete drug release within the 12 min. The percent drug release in 12 min (Q12) and initial dissolution rate for formulation F3 was 94.22±1.08%, 9.26%/min. These were very much higher compared to conventional tablets containing pure drug (23.87±1.13%, 2.38%/min). The relative dissolution rate was found to be 2.14 and dissolution efficiency was found to be 67.52 and it is increased by 4.0 fold with F3 formulation compared to conventional tablets. Thus, it is concluded that the formulation of guar gum as disintegrating agent is a suitable approach to improve the solubility and dissolution rate of Ezetimibe than pure form of drug.