MORPHOLOGICAL FEATURES OF THE DAMAGE OF MICROVASCULATURE AND CHANGES IN THE LEVELS OF ADIPOSE TISSUE HORMONE VISFATIN IN RAT MODEL OF ALIMENTARY OBESITY

We performed a morphological analysis (on the light-optical and ultrastructural levels) of changes in microvasculature of brain, kidneys, and red blood cells, we also analyzed the adipocytokine visfatin levels in a rat model of alimentary obesity. The purpose of the research was to study the earliest morphological changes of microvasculature and analyze the levels of the adipose tissue hormone visfatin in experimental animal (rats) model of alimentary obesity. It was determined that the brain was a major target of alimentary obesity, which lead to ischemic encephalopathy. The level of the hormone visfatin was directly dependent on the amount of fat tissue and indirectly on the level of total cholesterol and high density lipoprotein, and therefore had a direct impact on the development of inflammatory processes and microcirculatory disturbances observed in alimentary obesity.. The scientific novelty of this work was obtaining new ideas about structural and biochemical changes in alimentary obesity. Area of application ? pathological physiology.