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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.3, No. 1)

Publication Date:

Authors : ; ; ; ;

Page : 22-30

Keywords : Orodispersible tablets; Naratriptan; FTIR.;

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Orodispersible Tablets (ODT) of Naratriptan a typical anti migraine is highly appropriate, as it has ease of administration for patients who are mentally ill, disabled and uncooperative. It has better patient’s acceptance and compliance and other improved biopharmaceutical properties and efficiency compared with conventional oral dosage forms. In the present research work an attempt was made to design ODT by using sublimation method by addition of camphor as subliming agent, followed by effect of lubricants were resulted. The experiment was run with six batches containing different concentrations of subliming agents. On comparing all the batches of sublimation method SF4 shows higher dissolution rate was resulted due to rapid diffusion or porous nature of tablet. Among them camphor 5% is better subliming agent for formulation of ODT of Naratriptan. Vacuum drying employed to remove sublime salts at low temperature 40ºC for 2 hr. From the results of study we concluded that formulation SF4 (Mannitol, lactose monohydrate, Crospovidone, Aspartame Sodium starch glycolate, Magnesium stearate, Orange flavor Camphor) possesses good disintegration and dissolution rate profile. An FTIR studies reveal that there is no interaction of drug with excipients. The sublimation method can be used to prepare ODTs of several categories of drugs, which need rapid onset of action. Hence sublimation method of preparing tablet with a view of obtaining faster action of drug and would be advantageous in comparing to the currently conventional forms. Keywords: Orodispersible tablets, Naratriptan, FTIR.

Last modified: 2016-02-14 15:33:41