Ketofol as a Balanced Anesthetic for Procedural Sedation and Analgesia (PSA) in the Obese Oral Surgery Patient: a Commentary

A hallmark of oral and maxillofacial surgery is the administration of sedation and general anesthesia in the office setting. As part of their training, oral surgeons are required to function as anesthesia residents for a minimum of 5 months with commensurate levels of responsibility. The oral surgeon treats a variety of patients and must take increasing care to avoid and manage any untoward anesthetic events. “Ketofol” is a moniker for ketamine and propofol administered either independently or as a single-syringe admixture. Ketofol is hypothesized to possess the ideal profile for sedation because of the balance provided by both agents. This commentary aims to present the risks and benefits of ketofol and apply this knowledge to a patient population who may benefit the most from the combination.