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RP-HPLC METHOD DEVELOPMENT AND VALIDTION FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND RAMIPRIL IN PHARMACEUTICAL DOSAGE FORMS
Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.3, No. 2)Publication Date: 2016-03-03
Authors : M. Divya; G. Anusha; H. Padmalatha;
Page : 86-91
Keywords : Telmisartan; Ramipril; RP-HPLC; development; validation; simultaneous estimation.;
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Abstract
A simple, precise, accurate reverse phase high performance liquid chromatographic method has been developed and validated for the simultaneous estimation of Telmisartan and Ramipril in combined dosage forms. The mobile phase used was a mixture of % triethylamine : acetonitrile(55:45v/v). The elution was carried out at 260 nm. The method was validated in terms of suitability, precisicion , accuracy, linearity, ruggedness and robustness. The method can be successfully used to determine the drug content of marketed formulation. Key Words:Telmisartan,Ramipril, RP-HPLC, development, validation, simultaneous estimation.
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Last modified: 2016-03-05 02:43:52