FORMULATION DESIGN AND EVALUATION OF LAMIVUDINE MATRIX TABLETS

Objective: The main objective of present wrk is to formulate the controlled release tablet of Lamivudine using using hydrophilic matrix material (HPMC) along or in combination with hydrophobic polymer. Methods: The controlled release tablets of lamivudine were prepared employing different concentrations of HPMC,sodium alginate and acacia gum in different combinations as a rate retarding agent by Direct Compression. Results: Totally eight formulations were designed and are evaluated for hardness, friability, thickness, % drug content, in-vitro drug release. From the results it was concluded that all the formulation were found to be within the pharmacopoeial limits and the in-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, Conclusions: Thus the present studies clearly indicated that these formulations were found to be suitable for once a day matrix tablet administration Keywords: Lamivudine, Controlled release tablet, sodium alginate, acacia gum, HPMC