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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.3, No. 2)

Publication Date:

Authors : ; ; ;

Page : 142-152

Keywords : Lamivudine; Controlled release tablet; sodium alginate; acacia gum; HPMC;

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Objective: The main objective of present wrk is to formulate the controlled release tablet of Lamivudine using using hydrophilic matrix material (HPMC) along or in combination with hydrophobic polymer. Methods: The controlled release tablets of lamivudine were prepared employing different concentrations of HPMC,sodium alginate and acacia gum in different combinations as a rate retarding agent by Direct Compression. Results: Totally eight formulations were designed and are evaluated for hardness, friability, thickness, % drug content, in-vitro drug release. From the results it was concluded that all the formulation were found to be within the pharmacopoeial limits and the in-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, Conclusions: Thus the present studies clearly indicated that these formulations were found to be suitable for once a day matrix tablet administration Keywords: Lamivudine, Controlled release tablet, sodium alginate, acacia gum, HPMC

Last modified: 2016-03-05 02:51:02