Serum Calcium and Phosphorus Levels during Different Stages of Pregnancy

The aim of this study was to compare serum calcium and phosphate levels between pregnant women in different stages of pregnancy and healthy non-pregnant women aged 32 ± 3 yrs. This study discerned a significant reduction (P values 0.03, 0.04) in the serum calcium level in first (7.7 ± 0.34, 10.2 ± 0.43) second trimester (8.0 ± 0.39, 10.2 ± 0.43) whilst insignificant levels were found in third trimester between pregnant women and control group at P value 0.06 (9.7 ± 0.27, 10.2 ±0.43). Phosphorus levels were insignificant between different stages of pregnancy and between study and control group (P value 0.33, 0.31, 0.31) with mean ± SD for the first (3.16 ±0.36, 3.16 ±0.36), second (3.17 ±0.31, 3.16 ±0.36) and third (3.16 ±0.31, 3.16 ±0.36) trimester. Correlation showed weak negative correlation between calcium level in first and second trimester and very weak correlation in third trimester of pregnancy (R = -0.47, -0.58 and -0.22) and no correlation detected between phosphorus level and all stages of pregnancy (R = 0.00, 0.00, 0.00). This study concluded that pregnancy is associated with significant reduction in serum calcium level during the first and second trimester of pregnancy. Calcium level also correlates weakly negative with the duration of pregnancy. Phosphorus level does not affect either by circumstances of pregnancy nor its different stages. Human body resemble to demineralization bone calcium in order to attain normal calcium hemostasis.