Resolution of Seizures in A Child with Dravet Syndrome and Immunoglobulin G Subclasses Deficiency Treated with Valproic Acid, Intravenous Immunoglobulin, and Vagal Nerve Stimulator

Severe myoclonic epilepsy in infants, also known as Dravet syndrome, is a rare refractory form of epilepsy and its control requires a combination of several antiepileptic drugs. We describe a child who had Dravet syndrome unresponsive to a combination of drugs. Work-up for repeated infections revealed immunoglobulin G subclasses deficiency. Administration of intravenous immunoglobulin in addition to valproic acid did not control epilepsy but followed by Vagal Nerve Stimulator, resolution of seizures was sustained.