FORMULATION AND EVALUATION OF SUSTAINED RELEASE VALSARTAN MATRIX TABLET BY USING NATURAL GUMS

Valsartan is Angiotensin-II receptor antagonist used in anti-hypertensive drug. The present study is deals with formulation, optimization, evaluation of Sustained release Valsartan matrix tablet. The SR tablets were Prepared by direct compression method and formulated using different natural gums.ratios, formulation such as F1-F9. Gums like Xanthan gum and guar gum were used. Compatibility of drug with various excipients was studies. The compressed tablet were evaluated and showed compliance with Pharmacopoeial limits. The concentration of Xanthan gum and Guar gum were different in all formulations (F1-F9). All the formulations were evaluated for pre-compression parameters and weight variation, Hardness,friability, drug content, invitro dissolution studies. The formulation ‘F9’ was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 320.14±0.42%, Friability 0.30%, Swelling index 85%, drug content 98.91±0.32%, and in-vitro dissolution study 99.91±2.1% at the end of 15 hrs. keywords: Valsartan, Guar Gum, Xanthan Gum, Sustained Release Matrix Tablets, etc.