Evaluation of Proliferative Index (Ki 67) and Suppressor Gene (P53) Expression in Colon Polyps

Objective: The aim of this study is to evaluate the presence of Ki 67 proliferation zone of active areas and p53 mutation in colorectal polyps and to compare the results between the polyp types. Methods: Our study included 142 colon polyps. Studies based on the presence of dysplastic areas and dysmorphism in the polyp types that were considered to be non?neoplastic showed that a different pathway may have a role in malignant transformation. The cases were reclassified according to WHO 2010 classification. The tissue sections were stained by immunohistochemistry for Ki 67 and p53 Results: In our study Ki 67 staining was seen 74.5% in the lower zone of the crypt with HP. Ki 67 staining was seen in both the lower zone (40.9%) and the upper zone (56.1%) of the crypt with AP. In almost all cases, low rate of the p53 staining was observed in the ? lower zone of crypts. The rate of p53 staining in the upper ? zone of the crypts was 50% in AP cases. The staining ratio was low in HP and SSA/P Conclusion: The evaluation of polyp histopathology and Ki 67, p53, and molecular genetic with serologic characteristics of patients are required in parallel reviews.