SYNTHESIS, CHARACTERIZATION OF NEW HETEROCYCLIC RING BASED ON 2, 5-DIMERCAPTO1, 3, 4 -THIADIAZOLEJournal: BEST : International Journal of Humanities , Arts, Medicine and Sciences ( BEST : IJHAMS ) (Vol.4, No. 7)
Publication Date: 2016-07-31
Authors : SHETHA F. AL;
Page : 49-62
Keywords : 1; 3; 4- Thiadiazole Fused With 1; 2; 4-Triazole Ring; Schiff Base;
In this work preparation a number of heterocyclic compounds beginners of 2, 5 dimercapto -1, 3, 4- thiadiazole  created from interaction hydrazine hydrate with carbon disulphide in absolute ethanol. After then compound  reaction with ( 2mol) thiosemicarbazide to give triazolo derivation  and treatment (2mol) from chloroacetyle chloride with compound  in dry pyridine obtain on -3,6 dichloroacetamido 1,3,4 thiadiazole derivation. Then the compound  reaction with urea and thiourea to give 3, 6 disubstitution from oxazole and thiazole 1, 3, 4- thiodiazole derivation [4, 5]. The treatment of the compounds [4, 5] with derivation aromatic aldehyde to give Schiff base [6-9]. Schiff base treatment with (chloroacetyle chloride, sodium azide, mercaptoacetic acid) in order to give new derivation Schiff base compound β-Lactam [10-13], Tetrazole [14-17], Thiazolidinones [18-21]. The compound characterization was done by using [FT-IR, UV, H-NMR spectra and elemental analysis (C.H.N.S)].
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