Relationship between Mast Cells and Autoimmune Diseases

Mast Cells (MCs) are no longer considered as only effectors cell in allergic disorders, but also as important modulators of innate and adaptive immune responses. Increased numbers of MCs together with signs of their degranulation at sites of inflammation and tissue injury have been shown in studies of both human disease and animal models of autoimmune disorders. Despite this substantial evidence, MCs role in autoimmunity is still on debate. MCs can regulate the recruitment, survival and function of many immune cells. Therefore, they are able to enhance or suppress the initiation, magnitude and/ or continuance of immune responses in autoimmune conditions. Further studies are essential to gain a more detailed understanding of MCs participation in autoimmunity. Targeting MC may be of value in future prevention and treatment of autoimmune diseases.