FORMULATION,DEVELOPMENT AND EVALUATION OF ALBENDAZOLE ORAL JELLIES

Albendazole oral jellies using suitable natural and synthetic polymer as gelling agent with different concentrations. The benefits of these prepared jellies are increased bioavailability by-passing first pass metabolism. jellies were prepared by dispersing the gelling agent in water. Physical characteristics, pH, in vitro % drug release kinetics, content uniformity, spreadability, viscosity, IR spectral analysis, and stability studies were conducted.The prepared jellies of Albendazole found to be stable and there has no significant change in physical appearance, pH, viscosity etc. Thus, the study confirmed that the Albendazole oral jelly can be used as a possible alternative to recently available oral formulations. The prepared formulations are free from sugar crystals. Among the prepared formulation, formulation F2 (96.21%) and F10 (98.44%) respectively released in 30 min. was found to be promising. Stability studies, pH, viscosity, spreadability, on the promising. IR spectroscopic studies indicate that there were no drug-excipients interactions. keywords: Albendazole jellies, gelling agents , etc.